Induction of Cell-Mediated Immunity against Mycobacterium tuberculosis Using DNA Vaccines Encoding Cytotoxic and Helper T-Cell Epitopes of the 38-Kilodalton Protein

Cell-mediated immune responses are crucial in the protection against tuberculosis. In this study, we constructed DNA vaccines encoding cytotoxic T lymphocytes (CTL) and T helper cell (Th) epitopes of the 38-kDa lipoglycoprotein of Mycobacterium tuberculosis and analyzed and compared their immunogeni...

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Detalhes bibliográficos
Main Authors: Fonseca, Dora P. A. J., Benaissa-Trouw, Barry, van Engelen, Marloes, Kraaijeveld, Cees A., Snippe, Harm, Verheul, André F. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC98572/
https://ncbi.nlm.nih.gov/pubmed/11447158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.8.4839-4845.2001
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