Synthetic Polysaccharide Type 3-Related Di-, Tri-, and Tetrasaccharide–CRM(197) Conjugates Induce Protection against Streptococcus pneumoniae Type 3 in Mice

Di-, tri-, and tetrasaccharides, synthesized according to the chemical structure of pneumococcal polysaccharide type 3 (PS3), were coupled to the cross-reactive material (CRM(197)) of modified diphtheria toxin in different molar carbohydrate/protein ratios using the squarate coupling method. To stud...

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Bibliografiske detaljer
Main Authors: Benaissa-Trouw, Barry, Lefeber, Dirk J., Kamerling, Johannis P., Vliegenthart, Johannes F. G., Kraaijeveld, Kees, Snippe, Harm
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98553/
https://ncbi.nlm.nih.gov/pubmed/11402020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.7.4698-4701.2001
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