Protection against Anthrax Lethal Toxin Challenge by Genetic Immunization with a Plasmid Encoding the Lethal Factor Protein

The ability of genetic vaccination to protect against a lethal challenge of anthrax toxin was evaluated. BALB/c mice were immunized via gene gun inoculation with eucaryotic expression vector plasmids encoding either a fragment of the protective antigen (PA) or a fragment of lethal factor (LF). Plasm...

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Bibliographic Details
Main Authors: Price, Brian M., Liner, Adriane L., Park, Sukjoon, Leppla, Stephen H., Mateczun, Alfred, Galloway, Darrell R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC98526/
https://ncbi.nlm.nih.gov/pubmed/11401993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.7.4509-4515.2001
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