Mutation of the Gene Encoding Cytotoxic Necrotizing Factor Type 1 (cnf(1)) Attenuates the Virulence of Uropathogenic Escherichia coli

Cytotoxic necrotizing factor type 1 (CNF1) is a 115-kDa toxin that activates Rho GTPases and is produced by uropathogenic Escherichia coli (UPEC). While both epidemiological studies that link CNF1 production by E. coli with urinary tract disease and the cytopathic effects of CNF1 on cultured urinary...

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Pubblicato in:	Infect Immun
Autori principali:	Rippere-Lampe, Karen E., O'Brien, Alison D., Conran, Richard, Lockman, Hank A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Molecular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC98434/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11349064/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.6.3954-3964.2001
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