Mutation of the Gene Encoding Cytotoxic Necrotizing Factor Type 1 (cnf(1)) Attenuates the Virulence of Uropathogenic Escherichia coli

Cytotoxic necrotizing factor type 1 (CNF1) is a 115-kDa toxin that activates Rho GTPases and is produced by uropathogenic Escherichia coli (UPEC). While both epidemiological studies that link CNF1 production by E. coli with urinary tract disease and the cytopathic effects of CNF1 on cultured urinary...

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Detalhes bibliográficos
Main Authors: Rippere-Lampe, Karen E., O'Brien, Alison D., Conran, Richard, Lockman, Hank A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Molecular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC98434/
https://ncbi.nlm.nih.gov/pubmed/11349064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.6.3954-3964.2001
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