The C Terminus of Component C2II of Clostridium botulinum C2 Toxin Is Essential for Receptor Binding

The binary Clostridium botulinum C2 toxin consists of two separate proteins, the binding component C2II (80.5 kDa) and the actin-ADP-ribosylating enzyme component C2I (49.4 kDa). For its cytotoxic action, C2II binds to a cell membrane receptor and induces cell entry of C2I via receptor-mediated endo...

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Hauptverfasser: Blöcker, Dagmar, Barth, Holger, Maier, Elke, Benz, Roland, Barbieri, Joseph T., Aktories, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Molecular and Cellular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC98375/
https://ncbi.nlm.nih.gov/pubmed/10899856
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