Vaccination against the Intracellular Pathogens Leishmania major and L. amazonensis by Directing CD40 Ligand to Macrophages

CD40 ligand (CD40L) is a potent inducer of interleukin-12 (IL-12) production from macrophages and dendritic cells. We show that combining CD40L with antigen derived from Leishmania is an effective way to preferentially induce type 1 immune responses to the antigen and to vaccinate mice against subse...

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Bibliografiska uppgifter
Huvudupphovsmän: Chen, Gang, Darrah, Patricia A., Mosser, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2001
Ämnen:
Microbial Immunity and Vaccines
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC98284/
https://ncbi.nlm.nih.gov/pubmed/11292748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.5.3255-3263.2001
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