Antimycobacterial Agent Based on mRNA Encoding Human β-Defensin 2 Enables Primary Macrophages To Restrict Growth of Mycobacterium tuberculosis

Human macrophages are hosts for Mycobacterium tuberculosis, the causative agent of tuberculosis, which killed approximately 1.87 million people in 1997. Human alveolar macrophages do not express α- or β-defensins, broad-spectrum antimicrobial peptides which are expressed in macrophages from other sp...

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Bibliographic Details
Main Authors: Kisich, Kevin O., Heifets, Leonid, Higgins, Michael, Diamond, Gill
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC98208/
https://ncbi.nlm.nih.gov/pubmed/11254636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.4.2692-2699.2001
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