Micrococci and Peptidoglycan Activate TLR2→MyD88→IRAK→TRAF→NIK→IKK→NF-κB Signal Transduction Pathway That Induces Transcription of Interleukin-8

This study was done to elucidate the signal transduction pathway of interleukin-8 (IL-8) induction by gram-positive bacteria. Bacteria (micrococci) and peptidoglycan (PGN) induced transcription of IL-8 in HEK293 cells expressing Toll-like receptor 2 (TLR2) and CD14 but not in those expressing TLR1 o...

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Bibliographic Details
Main Authors: Wang, Qiuling, Dziarski, Roman, Kirschning, Carsten J., Muzio, Marta, Gupta, Dipika
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC98155/
https://ncbi.nlm.nih.gov/pubmed/11254583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.4.2270-2276.2001
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