Tumor Necrosis Factor Alpha Increases Human Cerebral Endothelial Cell Gb(3) and Sensitivity to Shiga Toxin

Hemolytic uremic syndrome (HUS) is associated with intestinal infection by enterohemorrhagic Escherichia coli strains that produce Shiga toxins. Globotriaosylceramide (Gb(3)) is the functional receptor for Shiga toxin, and tumor necrosis factor alpha (TNF-α) upregulates Gb(3) in both human macrovasc...

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Main Authors: Eisenhauer, Patricia B., Chaturvedi, Prasoon, Fine, Richard E., Ritchie, Andrew J., Pober, Jordan S., Cleary, Thomas G., Newburg, David S.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC98098/
https://ncbi.nlm.nih.gov/pubmed/11179369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.3.1889-1894.2001
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