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Cytosolic Delivery and Characterization of the TcdB Glucosylating Domain by Using a Heterologous Protein Fusion

TcdB from Clostridium difficile glucosylates small GTPases (Rho, Rac, and Cdc42) and is an important virulence factor in the human disease pseudomembranous colitis. In these experiments, in-frame genetic fusions between the genes for the 255 amino-terminal residues of anthrax toxin lethal factor (LF...

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Published in:Infect Immun
Main Authors: Spyres, Lea M., Qa'Dan, Maen, Meader, Amy, Tomasek, James J., Howard, Eric W., Ballard, Jimmy D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2001
Subjects:
Molecular Pathogenesis
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97927/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11119561/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.69.1.599-601.2001
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