Construction and Characterization of a Nonproliferative El Tor Cholera Vaccine Candidate Derived from Strain 638

In recent clinical assays, our cholera vaccine candidate strain, Vibrio cholerae 638 El Tor Ogawa, was well tolerated and immunogenic in Cuban volunteers. In this work we describe the construction of 638T, a thymidine auxotrophic version of improved environmental biosafety. In so doing, the thyA gen...

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Main Authors: Valle, Edgar, Ledón, Talena, Cedré, Bárbara, Campos, Javier, Valmaseda, Tania, Rodríguez, Boris, García, Luis, Marrero, Karen, Benítez, Jorge, Rodríguez, Sandra, Fando, Rafael
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Microbial Immunity and Vaccines
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC97727/
https://ncbi.nlm.nih.gov/pubmed/11035753
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