Construction and Characterization of a Nonproliferative El Tor Cholera Vaccine Candidate Derived from Strain 638

In recent clinical assays, our cholera vaccine candidate strain, Vibrio cholerae 638 El Tor Ogawa, was well tolerated and immunogenic in Cuban volunteers. In this work we describe the construction of 638T, a thymidine auxotrophic version of improved environmental biosafety. In so doing, the thyA gen...

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Autores principales: Valle, Edgar, Ledón, Talena, Cedré, Bárbara, Campos, Javier, Valmaseda, Tania, Rodríguez, Boris, García, Luis, Marrero, Karen, Benítez, Jorge, Rodríguez, Sandra, Fando, Rafael
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC97727/
https://ncbi.nlm.nih.gov/pubmed/11035753
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