Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype

Mutations in mitochondrial DNA (mtDNA) have been reported in cancer and are involved in the pathogenesis of many mitochondrial diseases. Uracil-DNA glycosylase, encoded by the UNG1 gene in Saccharomyces cerevisiae, repairs uracil in DNA formed due to deamination of cytosine. Our study demonstrates t...

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Publié dans:	Nucleic Acids Res
Auteurs principaux:	Chatterjee, Aditi, Singh, Keshav K.
Format:	Artigo
Langue:	Inglês
Publié:	Oxford University Press 2001
Sujets:	Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97606/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11812822/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.24.4935
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