The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

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Библиографические подробности
Главные авторы: Dekkers, Pascale E. P., ten Hove, Tessa, Lauw, Fanny N., Koene, Harry R., Lumley, Philip, van Deventer, Sander J. H., van der Poll, Tom
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2000
Предметы:
Host Response and Inflammation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC97526/
https://ncbi.nlm.nih.gov/pubmed/10769011
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