The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

Manylion Llyfryddiaeth

Cyhoeddwyd yn:	Infect Immun
Prif Awduron:	Dekkers, Pascale E. P., ten Hove, Tessa, Lauw, Fanny N., Koene, Harry R., Lumley, Philip, van Deventer, Sander J. H., van der Poll, Tom
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	American Society for Microbiology (ASM) 2000
Pynciau:	Host Response and Inflammation
Mynediad Ar-lein:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97526/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10769011/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.5.3036-3039.2000
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