The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

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Detalles Bibliográficos
Main Authors: Dekkers, Pascale E. P., ten Hove, Tessa, Lauw, Fanny N., Koene, Harry R., Lumley, Philip, van Deventer, Sander J. H., van der Poll, Tom
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2000
Assuntos:
Host Response and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC97526/
https://ncbi.nlm.nih.gov/pubmed/10769011
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