The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

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Main Authors: Dekkers, Pascale E. P., ten Hove, Tessa, Lauw, Fanny N., Koene, Harry R., Lumley, Philip, van Deventer, Sander J. H., van der Poll, Tom
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2000
Ábhair:
Host Response and Inflammation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC97526/
https://ncbi.nlm.nih.gov/pubmed/10769011
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