The Metalloproteinase Inhibitor GI5402 Inhibits Endotoxin-Induced Soluble CD27 and CD16 Release in Healthy Humans

Metalloproteinases have been implicated in the cleavage of a number of cell surface immune receptors. Oral administration of the metalloproteinase inhibitor GI5402 attenuated the release of soluble CD27 and CD16 into the circulation after intravenous endotoxin injection in healthy humans.

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Autors principals: Dekkers, Pascale E. P., ten Hove, Tessa, Lauw, Fanny N., Koene, Harry R., Lumley, Philip, van Deventer, Sander J. H., van der Poll, Tom
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Host Response and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC97526/
https://ncbi.nlm.nih.gov/pubmed/10769011
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