Attenuation of and Protection Induced by a Leucine Auxotroph of Mycobacterium tuberculosis

Attenuated mutants of Mycobacterium tuberculosis represent potential vaccine candidates for the prevention of tuberculosis. It is known that auxotrophs of a variety of bacteria are attenuated in vivo and yet provide protection against challenge with wild-type organisms. A leucine auxotroph of M. tub...

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Vydáno v:	Infect Immun
Hlavní autoři:	Hondalus, Mary K., Bardarov, Stoyan, Russell, Robert, Chan, John, Jacobs, William R., Bloom, Barry R.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2000
Témata:	Microbial Immunity and Vaccines
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97501/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10768986/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.5.2888-2898.2000
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