Inhibition of Vesicular Secretion in Both Neuronal and Nonneuronal Cells by a Retargeted Endopeptidase Derivative of Clostridium botulinum Neurotoxin Type A

Clostridial neurotoxins potently and specifically inhibit neurotransmitter release in defined cell types by a mechanism that involves cleavage of specific components of the vesicle docking/fusion complex, the SNARE complex. A derivative of the type A neurotoxin from Clostridium botulinum (termed LH(...

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Hlavní autoři: Chaddock, John A., Purkiss, John R., Friis, Lorna M., Broadbridge, Janice D., Duggan, Michael J., Fooks, Sarah J., Shone, Clifford C., Quinn, Conrad P., Foster, Keith A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2000
Témata:
Molecular and Cellular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC97463/
https://ncbi.nlm.nih.gov/pubmed/10768948
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