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Structures of engineered Clostridium botulinum neurotoxin derivatives
Targeted secretion inhibitors (TSIs) are a new class of engineered biopharmaceutical molecules derived from the botulinum neurotoxins (BoNTs). They consist of the metalloprotease light chain (LC) and translocation domain (Hn) of BoNT; they thus lack the native toxicity towards motor neurons but are...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
International Union of Crystallography
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3232119/ https://ncbi.nlm.nih.gov/pubmed/22139146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309111034671 |
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