Antibodies against the Plasmodium falciparum Receptor Binding Domain of EBA-175 Block Invasion Pathways That Do Not Involve Sialic Acids

The 175-kDa Plasmodium falciparum erythrocyte binding protein (EBA-175) binds to its receptor, sialic acids on glycophorin A. The binding region within EBA-175 is a cysteine-rich region identified as region II. Antibodies against region II block the binding of native EBA-175 to erythrocytes. We iden...

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Bibliographic Details
Main Authors: Narum, David L., Haynes, J. David, Fuhrmann, Steven, Moch, Kathy, Liang, Hong, Hoffman, Stephen L., Sim, B. Kim Lee
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Fungal and Parasitic Infections
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC97373/
https://ncbi.nlm.nih.gov/pubmed/10722589
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