Influence of Synthetic Antiendotoxin Peptides on Lipopolysaccharide (LPS) Recognition and LPS-Induced Proinflammatory Cytokine Responses by Cells Expressing Membrane-Bound CD14

Lipopolysaccharides (LPS) are proinflammatory bacterial products implicated in the pathogenesis of gram-negative sepsis and septic shock. Polymyxin B (PMB), a cyclic, cationic peptide antibiotic, inhibits biological activities of LPS through high-affinity binding to the lipid A moiety. Small synthet...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Iwagaki, Akitaka, Porro, Massimo, Pollack, Matthew
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Host Response and Inflammation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97326/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10678985/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.3.1655-1663.2000
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