Influence of Synthetic Antiendotoxin Peptides on Lipopolysaccharide (LPS) Recognition and LPS-Induced Proinflammatory Cytokine Responses by Cells Expressing Membrane-Bound CD14

Lipopolysaccharides (LPS) are proinflammatory bacterial products implicated in the pathogenesis of gram-negative sepsis and septic shock. Polymyxin B (PMB), a cyclic, cationic peptide antibiotic, inhibits biological activities of LPS through high-affinity binding to the lipid A moiety. Small synthet...

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Main Authors: Iwagaki, Akitaka, Porro, Massimo, Pollack, Matthew
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Host Response and Inflammation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC97326/
https://ncbi.nlm.nih.gov/pubmed/10678985
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