Phase 1 and Phase 2 Studies of Salmonella enterica Serovar Paratyphi A O-Specific Polysaccharide-Tetanus Toxoid Conjugates in Adults, Teenagers, and 2- to 4-Year-Old Children in Vietnam

Salmonella enterica serovar Paratyphi A O-specific polysaccharide (O-SP) was activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) and bound to tetanus toxoid (TT) with adipic acid dihydrazide as a linker (SPA-TT(1)) or directly (SPA-TT(2)). In mice, these two conjugates elicited...

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Main Authors: Konadu, Edward Y., Lin, Feng-Ying C., Hó, Vô Anh, Thuy, Nguyen Thi Thanh, Van Bay, Phan, Thanh, Tran Cong, Khiem, Ha Ba, Trach, Dang Duc, Karpas, Arthur B., Li, Jianping, Bryla, Dolores A., Robbins, John B., Szu, Shousun C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2000
Ábhair:
Microbial Immunity and Vaccines
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC97311/
https://ncbi.nlm.nih.gov/pubmed/10678970
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