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Phase 1 and Phase 2 Studies of Salmonella enterica Serovar Paratyphi A O-Specific Polysaccharide-Tetanus Toxoid Conjugates in Adults, Teenagers, and 2- to 4-Year-Old Children in Vietnam

Salmonella enterica serovar Paratyphi A O-specific polysaccharide (O-SP) was activated with 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) and bound to tetanus toxoid (TT) with adipic acid dihydrazide as a linker (SPA-TT(1)) or directly (SPA-TT(2)). In mice, these two conjugates elicited...

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Sparad:
I publikationen:Infect Immun
Huvudupphov: Konadu, Edward Y., Lin, Feng-Ying C., Hó, Vô Anh, Thuy, Nguyen Thi Thanh, Van Bay, Phan, Thanh, Tran Cong, Khiem, Ha Ba, Trach, Dang Duc, Karpas, Arthur B., Li, Jianping, Bryla, Dolores A., Robbins, John B., Szu, Shousun C.
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Microbiology (ASM) 2000
Ämnen:
Microbial Immunity and Vaccines
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97311/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10678970/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.3.1529-1534.2000
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