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New Method To Generate Enzymatically Deficient Clostridium difficile Toxin B as an Antigen for Immunization

The family of the large clostridial cytotoxins, encompassing Clostridium difficile toxins A and B as well as the lethal and hemorrhagic toxins from Clostridium sordellii, monoglucosylate the Rho GTPases by transferring a glucose moiety from the cosubstrate UDP-glucose. Here we present a new detoxifi...

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Udgivet i:Infect Immun
Principais autores: Genth, Harald, Selzer, Jörg, Busch, Christian, Dumbach, Jürgen, Hofmann, Fred, Aktories, Klaus, Just, Ingo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Molecular and Cellular Pathogenesis
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97253/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10678912/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.3.1094-1101.2000
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