Cleavage of a Recombinant Human Immunoglobulin A2 (IgA2)-IgA1 Hybrid Antibody by Certain Bacterial IgA1 Proteases

To understand more about the factors influencing the cleavage of immunoglobulin A1 (IgA1) by microbial IgA1 proteases, a recombinant human IgA2/IgA1 hybrid molecule was generated. In the hybrid, termed IgA2/A1 half hinge, a seven-amino-acid sequence corresponding to one half of the duplicated sequen...

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Bibliographic Details
Main Authors: Senior, Bernard W., Dunlop, James I., Batten, Margaret R., Kilian, Mogens, Woof, Jenny M.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Molecular and Cellular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC97164/
https://ncbi.nlm.nih.gov/pubmed/10639405
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