Exposure of N-Formyl-l-Methionyl-l-Leucyl-l-Phenylalanine-Activated Human Neutrophils to the Pseudomonas aeruginosa-Derived Pigment 1-Hydroxyphenazine Is Associated with Impaired Calcium Efflux and Potentiation of Primary Granule Enzyme Release

The effects of pathologically relevant concentrations (0.38 to 12.5 μM) of the proinflammatory, Pseudomonas aeruginosa-derived pigment 1-hydroxyphenazine (1-hp) on Ca(2+) metabolism and intracellular cyclic AMP (cAMP) in N-formyl-l-methionyl-l-leucyl-l-phenylalanine (FMLP; 1 μM)-activated human neut...

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Main Authors: Ramafi, Grace, Anderson, Ronald, Theron, Annette, Feldman, Charles, Taylor, Graham W., Wilson, Robert, Cole, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1999
Assuntos:
Host Response and Inflammation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC96865/
https://ncbi.nlm.nih.gov/pubmed/10496890
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