Triplex formation by morpholino oligodeoxyribonucleotides in the HER-2/neu promoter requires the pyrimidine motif

Triplex-forming oligonucleotides (TFOs) are good candidates to be used as site-specific DNA-binding agents. Two obstacles encountered with TFOs are susceptibility to nuclease activity and a requirement for magnesium for triplex formation. Morpholino oligonucleotides were shown in one study to form t...

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Библиографические подробности

Опубликовано в::	Nucleic Acids Res
Главные авторы:	Basye, Jenny, Trent, John O., Gao, Daquan, Ebbinghaus, Scot W.
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Oxford University Press 2001
Предметы:	Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96684/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11726697/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.23.4873
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