Lipopolysaccharide (LPS)-Binding Synthetic Peptides Derived from Serum Amyloid P Component Neutralize LPS

Lipopolysaccharide (LPS) is the major mediator of gram-negative septic shock. Molecules that bind LPS and neutralize its toxic effects could have important clinical applications. We showed that serum amyloid P component (SAP) neutralizes LPS. A SAP-derived peptide, consisting of amino acids 27 to 39...

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Hauptverfasser: de Haas, Carla J. C., van der Zee, Ruurd, Benaissa-Trouw, Barry, van Kessel, Kok P. M., Verhoef, Jan, van Strijp, Jos A. G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC96583/
https://ncbi.nlm.nih.gov/pubmed/10338482
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