Lipopolysaccharide (LPS)-Binding Synthetic Peptides Derived from Serum Amyloid P Component Neutralize LPS

Lipopolysaccharide (LPS) is the major mediator of gram-negative septic shock. Molecules that bind LPS and neutralize its toxic effects could have important clinical applications. We showed that serum amyloid P component (SAP) neutralizes LPS. A SAP-derived peptide, consisting of amino acids 27 to 39...

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Publié dans:	Infect Immun
Auteurs principaux:	de Haas, Carla J. C., van der Zee, Ruurd, Benaissa-Trouw, Barry, van Kessel, Kok P. M., Verhoef, Jan, van Strijp, Jos A. G.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1999
Sujets:	Host Response and Inflammation
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96583/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10338482/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.6.2790-2796.1999
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