Oligomerization of Anthrax Toxin Protective Antigen and Binding of Lethal Factor during Endocytic Uptake into Mammalian Cells

The protective antigen (PA) protein of anthrax toxin binds to a cellular receptor and is cleaved by cell surface furin to produce a 63-kDa fragment (PA63). The receptor-bound PA63 oligomerizes to a heptamer and acts to translocate the catalytic moieties of the toxin, lethal factor (LF) and edema fac...

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Pubblicato in:	Infect Immun
Autori principali:	Singh, Yogendra, Klimpel, Kurt R., Goel, Seema, Swain, Prabodha K., Leppla, Stephen H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1999
Soggetti:	Molecular and Cellular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96537/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10085027/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.4.1853-1859.1999
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