Oligomerization of Anthrax Toxin Protective Antigen and Binding of Lethal Factor during Endocytic Uptake into Mammalian Cells

The protective antigen (PA) protein of anthrax toxin binds to a cellular receptor and is cleaved by cell surface furin to produce a 63-kDa fragment (PA63). The receptor-bound PA63 oligomerizes to a heptamer and acts to translocate the catalytic moieties of the toxin, lethal factor (LF) and edema fac...

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Bibliographic Details
Main Authors: Singh, Yogendra, Klimpel, Kurt R., Goel, Seema, Swain, Prabodha K., Leppla, Stephen H.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Molecular and Cellular Pathogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC96537/
https://ncbi.nlm.nih.gov/pubmed/10085027
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