In Vivo Expression and Immunoadjuvancy of a Mutant of Heat-Labile Enterotoxin of Escherichia coli in Vaccine and Vector Strains of Vibrio cholerae

Vibrio cholerae secretes cholera toxin (CT) and the closely related heat-labile enterotoxin (LT) of Escherichia coli, the latter when expressed in V. cholerae. Both toxins are also potent immunoadjuvants. Mutant LT molecules that retain immunoadjuvant properties while possessing markedly diminished...

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Main Authors: Ryan, Edward T., Crean, Thomas I., John, Manohar, Butterton, Joan R., Clements, John D., Calderwood, Stephen B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Microbial Immunity and Vaccines
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC96516/
https://ncbi.nlm.nih.gov/pubmed/10085006
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