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The Pseudomonas aeruginosa Secretory Product Pyocyanin Inactivates α(1) Protease Inhibitor: Implications for the Pathogenesis of Cystic Fibrosis Lung Disease

α(1) Protease inhibitor (α(1)PI) modulates serine protease activity in the lung. Reactive oxygen species inactivate α(1)PI, and this process has been implicated in the pathogenesis of a variety of forms of lung injury. An imbalance of protease-antiprotease activity is also detected in the airways of...

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Sonraí Bibleagrafaíochta
Main Authors: Britigan, Bradley E., Railsback, Michelle A., Cox, Charles D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 1999
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC96448/
https://ncbi.nlm.nih.gov/pubmed/10024562
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