The Pseudomonas aeruginosa Secretory Product Pyocyanin Inactivates α(1) Protease Inhibitor: Implications for the Pathogenesis of Cystic Fibrosis Lung Disease

α(1) Protease inhibitor (α(1)PI) modulates serine protease activity in the lung. Reactive oxygen species inactivate α(1)PI, and this process has been implicated in the pathogenesis of a variety of forms of lung injury. An imbalance of protease-antiprotease activity is also detected in the airways of...

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Publicado en:	Infect Immun
Autores principales:	Britigan, Bradley E., Railsback, Michelle A., Cox, Charles D.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Materias:	Molecular and Cellular Pathogenesis
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10024562/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.3.1207-1212.1999
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