The Pseudomonas aeruginosa Secretory Product Pyocyanin Inactivates α(1) Protease Inhibitor: Implications for the Pathogenesis of Cystic Fibrosis Lung Disease

α(1) Protease inhibitor (α(1)PI) modulates serine protease activity in the lung. Reactive oxygen species inactivate α(1)PI, and this process has been implicated in the pathogenesis of a variety of forms of lung injury. An imbalance of protease-antiprotease activity is also detected in the airways of...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Britigan, Bradley E., Railsback, Michelle A., Cox, Charles D.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Molecular and Cellular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96448/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10024562/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.3.1207-1212.1999
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