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The Pseudomonas aeruginosa Secretory Product Pyocyanin Inactivates α(1) Protease Inhibitor: Implications for the Pathogenesis of Cystic Fibrosis Lung Disease

α(1) Protease inhibitor (α(1)PI) modulates serine protease activity in the lung. Reactive oxygen species inactivate α(1)PI, and this process has been implicated in the pathogenesis of a variety of forms of lung injury. An imbalance of protease-antiprotease activity is also detected in the airways of...

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Bibliographic Details
Main Authors: Britigan, Bradley E., Railsback, Michelle A., Cox, Charles D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC96448/
https://ncbi.nlm.nih.gov/pubmed/10024562
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