Cryptococcus neoformans Resides in an Acidic Phagolysosome of Human Macrophages

Recently, we demonstrated that human monocyte-derived macrophages (MDM) treated with chloroquine or ammonium chloride had markedly increased antifungal activity against the AIDS-related pathogen Cryptococcus neoformans. Both of these agents raise the lysosomal pH, which suggested that the increased...

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Publié dans:	Infect Immun
Auteurs principaux:	Levitz, Stuart M., Nong, Shu-Hua, Seetoo, Kurt F., Harrison, Thomas S., Speizer, Robert A., Simons, Elizabeth R.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1999
Sujets:	Fungal and Parasitic Infections
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96400/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9916104/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.2.885-890.1999
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