Characterization of Candidate Live Oral Salmonella typhi Vaccine Strains Harboring Defined Mutations in aroA, aroC, and htrA

The properties of two candidate Salmonella typhi-based live oral typhoid vaccine strains, BRD691 (S. typhi Ty2 harboring mutations in aroA and aroC) and BRD1116 (S. typhi Ty2 harboring mutations in aroA, aroC, and htrA), were compared in a number of in vitro and in vivo assays. BRD1116 exhibited an...

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Autores principales: Lowe, David C., Savidge, Tor C., Pickard, Derek, Eckmann, Lars, Kagnoff, Martin F., Dougan, Gordon, Chatfield, Steven N.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1999
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC96376/
https://ncbi.nlm.nih.gov/pubmed/9916080
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