The URA5 Gene Is Necessary for Histoplasma capsulatum Growth during Infection of Mouse and Human Cells

The Histoplasma capsulatum URA5 gene, which has recently been cloned and disrupted by allelic replacement, encodes orotidine-5′-monophosphate pyrophosphorylase. Inactivation of URA5 by either targeted or UV mutagenesis results in disruption of the pyrimidine biosynthetic pathway and uracil auxotroph...

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Detalles Bibliográficos

Publicado en:	Infect Immun
Autores principales:	Retallack, Diane M., Heinecke, Elizabeth L., Gibbons, Reta, Deepe, George S., Woods, Jon P.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Materias:	Fungal and Parasitic Infections
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96364/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9916068/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.2.624-629.1999
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