The URA5 Gene Is Necessary for Histoplasma capsulatum Growth during Infection of Mouse and Human Cells
The Histoplasma capsulatum URA5 gene, which has recently been cloned and disrupted by allelic replacement, encodes orotidine-5′-monophosphate pyrophosphorylase. Inactivation of URA5 by either targeted or UV mutagenesis results in disruption of the pyrimidine biosynthetic pathway and uracil auxotroph...
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| Udgivet i: | Infect Immun |
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| Principais autores: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1999
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96364/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9916068/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.2.624-629.1999 |
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