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The URA5 Gene Is Necessary for Histoplasma capsulatum Growth during Infection of Mouse and Human Cells

The Histoplasma capsulatum URA5 gene, which has recently been cloned and disrupted by allelic replacement, encodes orotidine-5′-monophosphate pyrophosphorylase. Inactivation of URA5 by either targeted or UV mutagenesis results in disruption of the pyrimidine biosynthetic pathway and uracil auxotroph...

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Bibliographic Details
Main Authors: Retallack, Diane M., Heinecke, Elizabeth L., Gibbons, Reta, Deepe, George S., Woods, Jon P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC96364/
https://ncbi.nlm.nih.gov/pubmed/9916068
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