Effects of Site-Directed Mutagenesis of Escherichia coli Heat-Labile Enterotoxin on ADP-Ribosyltransferase Activity and Interaction with ADP-Ribosylation Factors

Escherichia coli heat-labile enterotoxin (LT), an oligomeric protein with one A subunit (LTA) and five B subunits, exerts its effects via the ADP-ribosylation of G(sα), a guanine nucleotide-binding (G) protein that activates adenylyl cyclase. LTA also ADP-ribosylates simple guanidino compounds (e.g....

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	A. Stevens, Linda, Moss, Joel, Vaughan, Martha, Pizza, Mariagrazia, Rappuoli, Rino
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Molecular and Cellular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96305/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9864224/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.1.259-265.1999
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