Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin.

The Escherichia coli heat-labile enterotoxin (LT) is a potent inducer of mucosal immune responses. In a previous study (L. DeHaan, W. R. Verweij, M. Holtrop, E. Agsteribbe, and J. Wilschut, Vaccine 14:620-626, 1996), we have shown that efficient induction of an LTB-specific mucosal immune response b...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	de Haan, L, Verweij, W R, Feil, I K, Lijnema, T H, Hol, W G, Agsteribbe, E, Wilschut, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC174540/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8945598/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.64.12.5413-5416.1996
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