Suppression of Endotoxin- and Staphylococcal Exotoxin-Induced Cytokines and Chemokines by a Phospholipase C Inhibitor in Human Peripheral Blood Mononuclear Cells

Excessive release of proinflammatory cytokines from cells stimulated with lipopolysaccharide (LPS) or staphylococcal exotoxin (SE) mediates the pathophysiologic manifestations of septic shock. Tricyclodecan-9-yl (D609), an inhibitor of phosphatidylcholine-specific phospholipase C, suppressed LPS- or...

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Detalhes bibliográficos
Autor principal: Krakauer, Teresa
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Antibodies and Mediators of Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC96079/
https://ncbi.nlm.nih.gov/pubmed/11238238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.8.2.449-453.2001
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