A 12-Amino-Acid Segment, Present in Type s2 but Not Type s1 Helicobacter pylori VacA Proteins, Abolishes Cytotoxin Activity and Alters Membrane Channel Formation

Helicobacter pylori, a gram-negative bacterium associated with gastritis, peptic ulceration, and gastric adenocarcinoma in humans, secretes a protein toxin, VacA, that causes vacuolar degeneration of epithelial cells. Several different families of H. pylori vacA alleles can be distinguished based on...

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Detalhes bibliográficos
Main Authors: McClain, Mark S., Cao, Ping, Iwamoto, Hideki, Vinion-Dubiel, Arlene D., Szabo, Gabor, Shao, Zhifeng, Cover, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Enzymes and Proteins
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC95478/
https://ncbi.nlm.nih.gov/pubmed/11673417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.22.6499-6508.2001
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