Random Mutagenesis of Helicobacter pylori vacA To Identify Amino Acids Essential for Vacuolating Cytotoxic Activity

VacA is a secreted toxin that plays a role in Helicobacter pylori colonization of the stomach and may contribute to the pathogenesis of peptic ulcer disease and gastric cancer. In this study, we analyzed a library of plasmids expressing randomly mutated forms of recombinant VacA and identified 10 mu...

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Bibliografiske detaljer
Main Authors: McClain, Mark S., Czajkowsky, Daniel M., Torres, Victor J., Szabo, Gabor, Shao, Zhifeng, Cover, Timothy L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1695532/
https://ncbi.nlm.nih.gov/pubmed/16954403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00915-06
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