Positive Selection of Mutations Leading to Loss or Reduction of Transcriptional Activity of PrfA, the Central Regulator of Listeria monocytogenes Virulence

Transcription factor PrfA controls the expression of virulence genes essential for Listeria monocytogenes pathogenesis. To gain insight into the structure-function relationship of PrfA, we devised a positive-selection system to isolate mutations reducing or abolishing transcriptional activity. The s...

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Publikašuvnnas:	J Bacteriol
Váldodahkkit:	Herler, M., Bubert, A., Goetz, M., Vega, Y., Vazquez-Boland, J. A., Goebel, W.
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	American Society for Microbiology (ASM) 2001
Fáttát:	Genetics and Molecular Biology
Liŋkkat:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95447/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11544218/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.19.5562-5570.2001
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Positive Selection of Mutations Leading to Loss or Reduction of Transcriptional Activity of PrfA, the Central Regulator of Listeria monocytogenes Virulence

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