Positive Selection of Mutations Leading to Loss or Reduction of Transcriptional Activity of PrfA, the Central Regulator of Listeria monocytogenes Virulence

Transcription factor PrfA controls the expression of virulence genes essential for Listeria monocytogenes pathogenesis. To gain insight into the structure-function relationship of PrfA, we devised a positive-selection system to isolate mutations reducing or abolishing transcriptional activity. The s...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Herler, M., Bubert, A., Goetz, M., Vega, Y., Vazquez-Boland, J. A., Goebel, W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Genetics and Molecular Biology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95447/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11544218/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.19.5562-5570.2001
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