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Involvement of Domain 3 in Oligomerization by the Protective Antigen Moiety of Anthrax Toxin

Protective antigen (PA), a component of anthrax toxin, binds receptors on mammalian cells and is activated by a cell surface protease. The resulting active fragment, PA(63), forms ring-shaped heptamers, binds the enzymic moieties of the toxin, and translocates them to the cytosol. Of the four crysta...

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Udgivet i:J Bacteriol
Principais autores: Mogridge, Jeremy, Mourez, Michael, Collier, R. John
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Enzymes and Proteins
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95109/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11222612/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.6.2111-2116.2001
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